ea0021p125 | Cytokines and growth factors | SFEBES2009
Pass Chloe
, MacRae Vicky
, Ahmed Syed
, Farquharson Colin
Introduction: SOCS2 is an important negative regulator of post-natal growth, as demonstrated by the SOCS2 null overgrowth phenotype. We have used SOCS2−/− mice, alongside chondrocytes overexpressing SOCS2, to investigate the mode of action of SOCS2 at the epiphysis. SOCS2 maybe involved in growth retardation associated with chronic inflammatory disorders, therefore we studied LPS induced growth retardation in wild type (WT) and SOCS2−/−<...